Trypophobia, an aversion to patterns with small holes associated with anxiety, may cause symptoms like chills and nausea. Although not officially recognized by the APA, a trypophobia test can assess the aversion, affecting around 17% of people, particularly females and those with anxiety or OCD.

Treatment involves exposure therapy and cognitive-behavioral therapy; anti-anxiety medications are generally not recommended. Complications may include depression and stress. Relaxation techniques aid symptom management, and seeking professional help is advised for improved quality of life.