NCIS has witnessed several cast departures over its 19 seasons. Zoe McClellan, Cote de Pablo, and Michael Weatherly left due to various reasons, including creative differences. Polly Perrette, Adam Jamal Craig, and Lauren Holly departed amid conflicts or creative choices.

Sasha Alexander, Jennifer Esposito, and Emily Wickersham left for personal or career reasons. Dwayne Henry continued until the showrunner’s passing, and Miguel Ferrer played Owen Granger until his death in 2017.

Lucas Black prioritized personal life, and Jennifer Esposito reportedly left due to disagreements with the network. Polly Perrette’s exit involved tensions with Mark Harmon, stemming from a dog bite incident.